Blisters can sometimes develop from an illness or a toxic
reaction. Symptoms of a serious illness can include:
Shaking chills or fever.
A moderate to severe headache.
sense of illness (malaise).
Blisters may appear with a viral infection, such as
shingles, or after a bite from a poisonous spider,
such as a
brown recluse, or following a tick bite. Blisters may
also occur as a symptom of a toxic reaction to a medicine. This reaction is
Your blister or
blisters may not be related to another illness. You may have picked up a viral
illness, such as the
flu, at the same time you got a blister. It could be a
coincidence that the blister and signs of illness appeared at the same time.
You have a greater risk of developing an infection and
complications from a blister if you also have other conditions, such as
peripheral arterial disease.
Primary Medical Reviewer
William H. Blahd, Jr., MD, FACEP - Emergency Medicine
How this information was developed to help you make better health decisions.