A skin biopsy is a procedure in which a sample of skin tissue is removed, processed, and examined under a microscope.

Several different methods may be used to obtain a skin sample, depending on the size and location of the abnormal area of skin, called a skin lesion. The skin sample is placed in a solution, such as formaldehyde, or in a sterile container if infection is suspected. In each of these procedures, the tissue is processed and then examined under a microscope.

Skin biopsies most often are done to diagnose skin cancer, which may be suspected when an abnormal area of skin has changed color , shape , size, or appearance or has not healed after an injury. Skin cancers are the most common type of cancers.

Early diagnosis of a suspicious skin lesion and skin biopsy can help identify skin cancers and lead to early treatment.