Coronary artery disease happens when fatty deposits called plaque (say "plak") build up inside your coronary arteries. Those are the blood vessels that supply blood and oxygen to your heart. Plaque buildup may reduce the amount of blood that gets to your heart. Coronary artery disease can cause angina symptoms, such as chest pain or pressure. It can lead to a heart attack.
Coronary artery disease (also called CAD) is the most common type of heart disease. It's also the number one killer of both men and women in the United States.