Lupus and Antiphospholipid Antibody SyndromeSkip to the navigation
About 1 out of 3 people with lupus produce an antibody that attacks certain blood-clotting factors, which can cause the blood to clot easily. footnote 1 A person who has this antibody and has had blood clots is said to have antiphospholipid antibody syndrome. This can lead to mild or severe blood-clotting complications, including:
- Stroke , transient ischemic attack (TIA) , or heart attack .
- Deep vein thrombosis or pulmonary embolism .
- Multi-infarct dementia .
- Gangrene of fingers or toes.
- Kidney disease.
- Preeclampsia , premature birth, and miscarriage or stillbirth , apparently caused by blood circulation problems in the placenta .
A blood test can detect antiphospholipid antibodies. When diagnosed, the condition is usually treated with anticoagulants . Pregnant women with antiphospholipid antibody syndrome need to be closely monitored.
Primary Medical Reviewer Anne C. Poinier, MD - Internal Medicine
Specialist Medical Reviewer Nancy Ann Shadick, MD, MPH - Internal Medicine, Rheumatology
Current as ofFebruary 24, 2016
Current as of: February 24, 2016