If you have cancer, call your doctor if any of the following occur:

• You have new pain.
• Your drugs or other treatments are no longer working.
• Your pain medicine is not working long enough after each dose.
• You have new symptoms, such as having a hard time walking, eating, or urinating.
• You notice an unusual rash, or bowel or bladder changes.
• You have unexpected or poorly controlled side effects, such as nausea or vomiting, constipation, or diarrhea.
• Your pain makes it hard for you to do your daily activities, such as eating or sleeping.